Analyzing the Control of Mosquito-Borne Diseases by a Dominant Lethal Genetic System
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Motivated by the failure of current methods to control dengue fever, we formulate a mathematical model to assess the impact on the spread of a mosquito-borne viral disease of a strategy that releases adult male insects homozygous for a dominant, repressible, lethal genetic trait. A dynamic model for the female adult mosquito population, which incorporates the competition for female mating between released mosquitoes and wild mosquitoes, density-dependent competition during the larval stage, and realization of the lethal trait either before or after the larval stage, is embedded into a susceptible-exposed-infectious- susceptible human-vector epidemic model for the spread of the disease. For the special case in which the number of released mosquitoes is maintained in a fixed proportion to the number of adult female mosquitoes at each point in time, we derive mathematical formulas for the disease eradication condition and the approximate number of released mosquitoes necessary for eradication. Numerical results using data for dengue fever suggest that the proportional policy outperforms a release policy in which the released mosquito population is held constant, and that eradication in approximately 1 year is feasible for affected human populations on the order of 105 to 106, although the logistical considerations are daunting. We also construct a policy that achieves an exponential decay in the female mosquito population; this policy releases approximately the same number of mosquitoes as the proportional policy but achieves eradication nearly twice as fast.
2006-2007 CISAC Fellows Forum
The CISAC Fellows Forum showcases some of the vitally important work that has been accomplished at CISAC this year. Moderated by Scott Sagan, CISAC co-director, three scholars represent the promising work of CISAC fellows:
David Patel
Postdoctoral Fellow
"Islam, Identity, and Electoral Outcomes in Iraq"
Why has a cohesive national Shiite political identity emerged in Iraq while Sunni Arabs remain fractured? What does the United States need to understand about how differences between Shiite and Sunni clerical networks influence electoral successes?
David Patel's work focuses on questions of religious organizations and collective action in the Middle East. In fall 2007, he will join the faculty at Cornell University as an assistant professor of political science.
Jacob Shapiro
"Mis-overestimating Terrorism: The Problems Terrorists Face and How to Make Them Worse"
Terrorist organizations face substantial internal challenges which make them vulnerable to government action. Careful counter terrorism strategies can exploit these organizational pathologies.
Jacob Shapiro is a graduate student in political science at Stanford University and a CISAC predoctoral fellow. His research focuses on the economic forces that motivate terrorist organizations and the organizational challenges that these groups face.
Rebecca Slayton
"Technology Limited: How Scientists Do and Don't Influence U.S. Defense Policy"
In the United States, high technology is a favorite solution to national security problems. But how do we know when complex technology has reached its limits? The rancorous debate over missile defense shows how experts use science to authoritatively frame options and thus influence the making of defense policy.
Rebecca Slayton is a lecturer in the Science, Technology and Society Program at Stanford University and a CISAC affiliate. In 2004-2005 she was a CISAC science fellow. Slayton's research examines the relationships between technocrats, academia, and the media.
Bechtel Conference Center
Scott D. Sagan
CISAC
Stanford University
Encina Hall, E202
Stanford, CA 94305-6165
Scott D. Sagan is the Caroline S.G. Munro Professor of Political Science, the Bass University Fellow in Undergraduate Education, and a Senior Fellow at the Center for International Security and Cooperation, where he previously served as the social science co-director. He is the Inaugural Harry Frank Guggenheim Fellow for Nuclear Ethics and Security at the Carnegie Council for Ethics in International Affairs (2026-2027). Sagan also serves as co-chair of the American Academy of Arts and Sciences’ Committee on International Security Studies. Before joining the Stanford faculty, he was a lecturer in the Department of Government at Harvard University and served as special assistant to the director of the Organization of the Joint Chiefs of Staff in the Pentagon.
Sagan is the author of Moving Targets: Nuclear Strategy and National Security (Princeton University Press, 1989); The Limits of Safety: Organizations, Accidents, and Nuclear Weapons (Princeton University Press, 1993); and, with co-author Kenneth N. Waltz, The Spread of Nuclear Weapons: An Enduring Debate (W.W. Norton, 2012). He is the co-editor of Insider Threats (Cornell University Press, 2017) with Matthew Bunn; and co-editor of The Fragile Balance of Terror (Cornell University Press, 2022) with Vipin Narang. Sagan was also the guest editor of a two-volume special issue of Daedalus: Ethics, Technology, and War (Fall 2016) and The Changing Rules of War (Winter 2017).
Recent publications include “Creeds and Contestation: How US Nuclear and Legal Doctrine Influence Each Other,” with Janina Dill, in a special issue of Security Studies (December 2025); “Kettles of Hawks: Public Opinion on the Nuclear Taboo and Noncombatant Immunity in the United States, United Kingdom, France, and Israel”, with Janina Dill and Benjamin A. Valentino in Security Studies (February 2022); “The Rule of Law and the Role of Strategy in U.S. Nuclear Doctrine” with Allen S. Weiner in International Security (Spring 2021); “Does the Noncombatant Immunity Norm Have Stopping Power?” with Benjamin A. Valentino in International Security (Fall 2020); and “Just War and Unjust Soldiers: American Public Opinion on the Moral Equality of Combatants” and “On Reciprocity, Revenge, and Replication: A Rejoinder to Walzer, McMahan, and Keohane” with Benjamin A. Valentino in Ethics & International Affairs (Winter 2019).
In 2022, Sagan was awarded Thérèse Delpech Memorial Award from the Carnegie Endowment for International Peace at their International Nuclear Policy Conference. In 2017, he received the International Studies Association’s Susan Strange Award which recognizes the scholar whose “singular intellect, assertiveness, and insight most challenge conventional wisdom and intellectual and organizational complacency" in the international studies community. Sagan was also the recipient of the National Academy of Sciences William and Katherine Estes Award in 2015, for his work addressing the risks of nuclear weapons and the causes of nuclear proliferation. The award, which is granted triennially, recognizes “research in any field of cognitive or behavioral science that advances understanding of issues relating to the risk of nuclear war.” In 2013, Sagan received the International Studies Association's International Security Studies Section Distinguished Scholar Award. He has also won four teaching awards: Stanford’s 1998-99 Dean’s Award for Distinguished Teaching; Stanford's 1996 Hoagland Prize for Undergraduate Teaching; the International Studies Association’s 2008 Innovative Teaching Award; and the Monterey Institute for International Studies’ Nonproliferation Education Award in 2009.
Rebecca Slayton
Slayton’s research and teaching examine the relationships between and among risk, governance, and expertise, with a focus on international security and cooperation since World War II. Slayton’s current book project, Shadowing Cybersecurity, examines the historical emergence of cybersecurity expertise. Shadowing Cybersecurity shows how efforts to establish credible expertise in corporate, governmental, and non-governmental contexts have produced varying and sometimes conflicting expert practices. Nonetheless, all cybersecurity experts wrestle with the irreducible uncertainties that characterize intelligent adversaries, and the fundamental inability to prove that systems are secure. The book shows how cybersecurity experts have paradoxically gained credibility by making threats and vulnerabilities visible, while acknowledging that more always remain in the shadows.
Slayton’s first book, Arguments that Count: Physics, Computing, and Missile Defense, 1949-2012 (MIT Press, 2013), shows how the rise of a new field of expertise in computing reshaped public policies and perceptions about the risks of missile defense in the United States. In 2015, Arguments that Count won the Computer History Museum Prize. In 2016, Slayton was awarded a National Science Foundation CAREER grant for her project “Enacting Cybersecurity Expertise.” In 2019, Slayton was also a recipient of the United States Presidential Early Career Award for Scientists and Engineers, for her NSF CAREER project.
Anatomy of a Project to Produce Nuclear Weapons
The anatomy of a program to develop a first nuclear weapon was analyzed as a precursor to comparison of potential counter-proliferation activities. In this talk we discuss this precursor task. The weapon and path selected for this analysis was covert development of a gun-type fission device using uranium enriched by centrifuge technology. The rationale for this selection is described. The anatomy was developed by identifying and sequencing each task required to ultimately assemble a single working nuclear explosive device and to provide a limited follow-on production capability. Tasks involve acquisition of materials, design and development of components including manufacturing tools and equipment, design and construction of facilities, operation of the facilities, assembly and integration of the components, and test and evaluation of the components and assembled device. Critical aspects of these steps will be discussed in the presentation. For each task the resources required (time, manpower, utilities, feed materials, and equipment) and their associated costs were estimated. These were inserted into standard project management tools. This permitted easy determination of overall costs and program duration as well as establishing a critical program path. The significance of this information and its use in one potential counter-proliferation activity is described as are potential extensions of this process to analysis of other proliferation pathways.
Robert C. Harney is an associate professor of systems engineering at the Naval Postgraduate School and is the Naval Sea Systems Command Chair of Total Ship Systems Engineering (Combat Systems). He received the BS degree in chemistry and physics from Harvey Mudd College in 1971 and the PhD in applied science from the University of California, Davis in 1976. His entire career has been spent in the field of national defense, working at Lawrence Livermore National Laboratory, M.I.T. Lincoln Laboratory, and Martin Marietta Corporation before joining the Naval Postgraduate School in 1995. He teaches courses in sensor systems, weapon systems, and systems engineering. His primary research interests are in advanced sensor systems, unconventional weapons of mass destruction, and counter-terrorism.
Reuben W. Hills Conference Room
DNA for Peace: The Balance Between Biosciences for Development and Security
One of the world's greatest ethical challenges is the inequities in global health. Life expectancy in the United States is about 80 years and rising, while in many parts of the developing world, particularly in Africa as a result of HIV/AIDS, it is 40 years and falling. On the "bright side," the globalization of life sciences is key force to improve health in the developing world. For example, the rise of the Indian biotechnology industry has improved availability of vaccines and programs like the Grand Challenges in Global Health Initiative funded by the Bill and Melinda Gates Foundation provide hope for upstream discovery science against global health problems. However, on the "dark side," the globalization of life sciences poses risks to global biosecurity including bioterrorism by non-state actors.
This lecture will explore how to optimize the benefits of the "bright side," and mitigate the risks of the "dark side," of the globalization of life sciences. Dr. Singer will argue that the biological case is different from the nuclear case and demands a different approach, and explore the potential role of the United Nations in enhancing global biosecurity.
Peter A. Singer is senior scientist at the McLaughlin Rotman Centre, University Health Network; professor of medicine, University of Toronto; co-director of the Canadian Program in Genomics and Global Health; and a distinguished investigator of the Canadian Institutes of Health Research. He studied internal medicine at the University of Toronto, medical ethics at the University of Chicago, public health at Yale University, and management at Harvard Business School. Between 1995 and 2006, Singer was Sun Life Financial Chair in Bioethics, director of the University of Toronto Joint Centre for Bioethics, and director of the World Health Organization Collaborating Centre for Bioethics at the University of Toronto.
History Corner, Building 200, Room 002
Implementing UN Security Council Resolution 1540
On April 28, 2004, the United Nations Security Council, acting under Chapter VII of the UN Charter, unanimously passed UNSC 1540. The resolution "decided that all States shall refrain from providing any form of support to non-state actors" attempting to obtain or use weapons of mass destruction, "adopt and enforce appropriate effective laws" to that effect, and "take and enforce effective measures to "prevent the proliferation of" WMD. To carry out its part of this mandate, the UNSC established and renewed a Committee, which has mainly and usefully assisted States in adopting "appropriate effective laws." This study, in collaboration with Committee members, has focused on implementation mechanisms and indicators of performance in border and exports controls, securing materiel and facilities, and adapting controls to State needs. We conclude that the most meaningful measures of implementation need to be more broadly adopted and that the 1540 Committee needs a more extensive staff in order to extend its role to disseminate States' experience with those measures. We also conclude that mechanisms need to be developed to facilitate information sharing between the Committee and the private sector.
Michael May is a professor emeritus (research) in the Stanford University School of Engineering and a senior fellow with the Freeman Spogli Institute for International Studies at Stanford University. He is the former co-director of Stanford University's Center for International Security and Cooperation, having served seven years in that capacity through January 2000. May is a director emeritus of the Lawrence Livermore National Laboratory, where he worked from 1952 to 1988, with some brief periods away from the Laboratory. While there, he held a variety of research and development positions, serving as director of the Laboratory from 1965 to 1971. May was a technical adviser to the Threshold Test Ban Treaty negotiating team; a member of the U.S. delegation to the Strategic Arms Limitation Talks; and at various times has been a member of the Defense Science Board, the General Advisory Committee to the AEC, the Secretary of Energy Advisory Board, the RAND Corporation Board of Trustees, and the Committee on International Security and Arms Control of the National Academy of Sciences. He is a member of the Council on Foreign Relations and the Pacific Council on International Policy, and a Fellow of the American Physical Society and the American Association for the Advancement of Science. May received the Distinguished Public Service and Distinguished Civilian Service Medals from the Department of Defense, and the Ernest Orlando Lawrence Award from the Atomic Energy Commission, as well as other awards. His current research interests are in the area of nuclear and terrorism, energy, security and environment, and the relation of nuclear weapons and foreign policy.
Chaim Braun is a vice president of Altos Management Partners, Inc., and a CISAC science fellow and affiliate. He is a member of the Near-Term Deployment and the Economic Cross-Cut Working Groups of the Department of Energy (DOE) Generation IV Roadmap study. He conducted several nuclear economics-related studies for the DOE Nuclear Energy Office, the Energy Information Administration, the Electric Power Research Institute, the Nuclear Energy Institute, Non-Proliferation Trust International, and others. Braun has worked as a member of Bechtel Power Corporation's Nuclear Management Group, and led studies on power plant performance and economics used to support maintenance services. Braun has worked on a study of safeguarding the Agreed Framework in North Korea, he was the co-leader of a NATO Study of Terrorist Threats to Nuclear Power Plants, led CISAC's Summer Study on Terrorist Threats to Research Reactors, and most recently co-authored an article with CISAC Co-Director Chris Chyba on nuclear proliferation rings. His research project this year is entitled "The Energy Security Initiative and a Nuclear Fuel Cycle Center: Two Enhancement Options for the Current Non-Proliferation Regime."
Allen Weiner is an associate professor of law (teaching) at the Stanford Law School, as well as the inaugural Warren Christopher Professor of the Practice of International Law and Diplomacy, a chair held jointly by FSI and the Stanford Law School. He is also an affiliated faculty member at CISAC. His expertise is in the field of public international law and the foreign relations law of the United States. His work focuses on the effect of positive international law rules on the conduct of foreign relations and other implications for the behavior of states, courts (both national and international), and other international actors. Current research interests focus on international law and the response to the contemporary security threats of international terrorism and the proliferation of weapons of mass destruction. He teaches courses in public international law and international criminal law at Stanford Law School. Before coming to Stanford, Weiner served for 12 years as a career attorney in the U.S. Department of State. He served in the Office of the Legal Adviser in Washington, D.C. (1990-1996) and at the U.S. Embassy in The Hague (1996-2001), most recently as legal counselor, in which capacity he served as the U.S. Government's principal day-to-day interlocutor with the international legal institutions in The Hague, including the International Court of Justice, the International Criminal Tribunal for the Former Yugoslavia, and the Iran-United States Claims Tribunal. He received a BA from Harvard College and a JD from Stanford Law School.
Roger Speed is a physicist formerly with the Lawrence Livermore National Laboratory and now an affiliate of CISAC. He has also worked at the National Academy of Sciences, at R&D Associates, and, as a Peace Fellow, at the Hoover Institution, where he wrote a book on strategic nuclear policy. He has served on a number of defense-related committees, including ones for the Office of Undersecretary of Defense for Policy, the American Physical Society, the U.S. Navy (Non-Acoustic ASW Panel), the National Academy of Sciences, and the Air Force Space and Missile Systems Organization. He has conducted a broad range of national security studies for the Department of Defense, Department of Energy, and Central Intelligence Agency in such areas as arms control, strategic deterrence, nuclear war, ballistic missile defense, nuclear weapons safety, and the survivability of strategic systems.
Reuben W. Hills Conference Room
Allen S. Weiner
Stanford Law School
559 Nathan Abbott Way
Neukom Faculty Office Building, Room N238
Stanford, CA 94305-8610
Allen S. Weiner is senior lecturer in law and director of the Stanford Program in International Law at Stanford Law School. He is also the co-director of the Stanford Center on International Conflict and Negotiation. He is an international legal scholar with expertise in such wide-ranging fields as international and national security law, the law of war, international conflict resolution, and international criminal law (including transitional justice). His scholarship focuses on international law and the response to the contemporary security threats of international terrorism, the proliferation of weapons of mass destruction, and situations of widespread humanitarian atrocities. He also explores the relationship between international and domestic law in the context of asymmetric armed conflicts between the United States and nonstate groups and the response to terrorism. In the realm of international conflict resolution, his highly multidisciplinary work analyzes the barriers to resolving violent political conflicts, with a particular focus on the Israeli-Palestinian conflict. Weiner’s scholarship is deeply informed by experience; for more than a decade he practiced international law in the U.S. Department of State, serving as an attorney-adviser in the Office of the Legal Adviser and as legal counselor at the U.S. Embassy in The Hague. In those capacities, he advised government policy-makers, negotiated international agreements, and represented the United States in litigation before the Iran-United States Claims Tribunal, the International Criminal Tribunal for the Former Yugoslavia, and the International Court of Justice. He teaches courses in public international law, international conflict resolution, and international security matters at Stanford Law School.
Weiner is the author of "Constitutions as Peace Treaties: A Cautionary Tale for the Arab Spring” in the Stanford Law Review Online (2011) and co-author (with Barry E. Carter) of International Law (6th ed. 2011). Other publications include “The Torture Memos and Accountability" in the American Society of International Law Insight (2009), "Law, Just War, and the International Fight Against Terrorism: Is It War?", in Intervention, Terrorism, and Torture: Contemporary Challenges to Just War Theory (Steven P. Lee, ed.) (2007), ”Enhancing Implementation of U.N. Security Council Resolution 1540: Report of the Center on International Security and Cooperation” (with Chaim Braun, Michael May & Roger Speed) (September 2007), and "The Use of Force and Contemporary Security Threats: Old Medicine for New Ills?", Stanford Law Review (2006).
Weiner has worked on several Supreme Court amicus briefs concerning national security and international law issues, including cases brought involving "war on terror" detainees. He has also submitted petitions before the United Nations Working Group on Arbitrary Detention on behalf of Vietnamese social and political activists detained by their governing for the exercise of free speech rights.
Weiner earned a BA from Harvard College and a JD from Stanford Law School.
The Window of Vulnerability That Wasn't: New Data on Soviet Strategic Capabilities
During the strategic modernization program that the Soviet Union undertook in the 1970s, it deployed a large number of multiple-warhead ballistic missiles. This deployment raised concerns in the United States about vulnerability of its land-based missile force and was one of the factors that contributed to the military buildup that the United States undertook in the late 1970s-early 1980s. The newly available documents that contain evidence of the Soviet missile programs demonstrate that the "window of vulnerability" did not exist and provide some insight into the Soviet modernization program.
Pavel Podvig joined CISAC as a research associate in 2004. Before that he was a researcher at the Center for Arms Control, Energy and Environmental Studies at the Moscow Institute of Physics and Technology (MIPT). He worked as a visiting researcher with the Security Studies Program at MIT and with the Program on Science and Global Security at Princeton University, and he taught physics in MIPT's General Physics Department for more than ten years.
Podvig graduated with honors from the Moscow Institute of Physics and Technology in 1988, with a degree in physics. In 2004 he received a PhD in political science from the Moscow Institute of World Economy and International Relations.
His research has focused on technical and political issues of missile defense, space security, U.S.-Russian relations, structure and capabilities of the Russian strategic forces, and nuclear nonproliferation. He was the head of the Russian Strategic Nuclear Forces research project and the editor of a book of the same title, which is considered a definitive source of information on Russian strategic forces.
Reuben W. Hills Conference Room
Pavel Podvig
Pavel Podvig is an independent analyst based in Geneva, where he runs his research project, "Russian Nuclear Forces." He is also a Senior Research Fellow at the UN Institute for Disarmament Research and a researcher with the Program on Science and Global Security at Princeton University. Pavel Podvig started his work on arms control at the Center for Arms Control Studies at the Moscow Institute of Physics and Technology (MIPT), which was the first independent research organization in Russia dedicated to analysis of technical issues of disarmament and nonproliferation. Pavel Podvig led the Center for Arms Control Studies project that produced the book, Russian Strategic Nuclear Forces (MIT Press, 2001). In recognition of his work in Russia, the American Physical Society awarded Podvig the Leo Szilard Lectureship Award of 2008 (with Anatoli Diakov). Podvig worked with the Program on Science and Global Security at Princeton University, the Security Studies Program at MIT, and the Center for International Security and Cooperation at Stanford University. His current research focuses on the Russian strategic forces and nuclear weapons complex, as well as technical and political aspects of nuclear nonproliferation, disarmament, missile defense, and U.S.-Russian arms control process. Pavel Podvig is a member of the International Panel on Fissile Materials. He has a physics degree from MIPT and PhD in political science from the Moscow Institute of World Economy and International Relations.
For a list of publications, please visit http://russianforces.org/podvig/.
Thoughts on the Day After
This paper analyzes what might be expected to happen if a 10-kiloton nuclear bomb exploded in a U.S. city; the example used for this analysis is San Francisco. The analysis draws from research projects the author has done in recent years for the Department of Homeland Security and other government organizations, including observing and providing critique on TOPOFF 2 (Top Officials), an exercise of federal, state, and local emergency response systems to terrorist attacks. The paper summarizes a number of talks the author has given to students and professionals working on security issues.
Showing off the Soviet State: How Public Representations of Nuclear Technologies Constructed Ideal Citizens
Sonja Schmid (speaker) is a social science research associate at Stanford University. Having received her Ph.D. in Science & Technology Studies from Cornell University, she is now a science fellow at the Center for International Security and Cooperation, and affiliated with the Program in Science, Technology and Society at Stanford. Her research has focused on understanding complex decision-making processes at the interface between science, technology, and the state in the Cold War Soviet context, and is based on extensive archival research and narrative interviews with nuclear energy specialists in Russia. She is currently working on a book about reactor design choices and the development of the civilian nuclear industry in the Soviet Union. In addition, she is involved in an international research project on Cold War Technopolitics and Colonialism, where she works on Soviet technology transfer to Central and Eastern Europe. Her research interests also include risk communication, and the popularization of science and technology, subjects on which she has published in the past.
Rebecca Slayton (respondent) is a lecturer in the Science, Technology and Society Program at Stanford University and a CISAC affiliate. In 2004-2005 she was a CISAC science fellow. Her research examines how technical judgments are generated, taken up, and given significance in international security contexts. She is currently working on a book which uses the history of the U.S. ballistic missile defense program to study the relationships between and among technology, expertise, and the media. Portions of this work have been published in journals such as History and Technology and have been presented at academic conferences. As a postdoctoral fellow in the Science, Technology, and Society Program at the Massachusetts Institute of Technology, she recently completed an NSF-funded project entitled Public Science: Discourse about the Strategic Defense Initiative, 1983-1988. As a physical chemist, she developed ultrafast laser experiments in condensed matter systems and published several articles in physics journals. She also received the AAAS Mass Media Science and Engineering Fellowship in 2000, and has worked as a science journalist for a daily paper and for Physical Review Focus. She earned her doctorate in chemistry from Harvard University in 2002.
Reuben W. Hills Conference Room
Rebecca Slayton
Slayton’s research and teaching examine the relationships between and among risk, governance, and expertise, with a focus on international security and cooperation since World War II. Slayton’s current book project, Shadowing Cybersecurity, examines the historical emergence of cybersecurity expertise. Shadowing Cybersecurity shows how efforts to establish credible expertise in corporate, governmental, and non-governmental contexts have produced varying and sometimes conflicting expert practices. Nonetheless, all cybersecurity experts wrestle with the irreducible uncertainties that characterize intelligent adversaries, and the fundamental inability to prove that systems are secure. The book shows how cybersecurity experts have paradoxically gained credibility by making threats and vulnerabilities visible, while acknowledging that more always remain in the shadows.
Slayton’s first book, Arguments that Count: Physics, Computing, and Missile Defense, 1949-2012 (MIT Press, 2013), shows how the rise of a new field of expertise in computing reshaped public policies and perceptions about the risks of missile defense in the United States. In 2015, Arguments that Count won the Computer History Museum Prize. In 2016, Slayton was awarded a National Science Foundation CAREER grant for her project “Enacting Cybersecurity Expertise.” In 2019, Slayton was also a recipient of the United States Presidential Early Career Award for Scientists and Engineers, for her NSF CAREER project.