The USSR's anti-plague system had four main responsibilities: monitor natural foci of endemic dread diseases such as plague, tularemia, anthrax, and Crimean-Congo hemorrhagic fever; protect the nation from imported exotic diseases (e.g., cholera and smallpox); protect the nation from biological warfare; and perform tasks for the Soviet offensive biological weapons program. Although the anti-plague system appears to have had successes in public health, its work undoubtedly was compromised by excessive secrecy, which led to anti-plague scientists having to overcome substantial barriers before being able to communicate with colleagues in other Soviet public health agencies, publish the results of their work, and undertake travel to non-socialist countries. This system disintegrated after December 1991, but was resurrected as elements of the newly independent states' health systems.

Reporting on the findings of a recently concluded project carried out by the Center for Nonproliferation Studies (CNS), I will discuss: (1) the threats that the anti-plague systems' human resources, pathogen culture collections, and equipment pose to international security; (2) the promises these systems hold, should they regain their former level of scientific/technical capability, for enhancing international public health; and (3) current activities by U.S. government agencies to lessen the security and safety threats of these systems and, simultaneously, increase their public health capabilities. As appropriate, I will illustrate the presentation with photos taken by CNS personnel in the course of having visited more than 40 anti-plague institutes and stations.

Dr. Raymond Zilinskas worked as a clinical microbiologist for 16 years, after graduating from California State University at Northridge with a BA in Biology, and from University of Stockholm with a Filosofie Kandidat in Organic Chemistry. He then commenced graduate studies at the University of Southern California. His dissertation addressed policy issues generated by recombinant DNA research, including the applicability of genetic engineering techniques for military and terrorist purposes. After earning a PhD, Dr. Zilinskas worked at the U.S. Office of Technology Assessment (1981-1982), United Nations Industrial Development Organization (1982-1986), and University of Maryland Biotechnology Institute (UMBI) (1987-1998). In addition, he was an Adjunct Associate Professor at the Department of International Health, School of Hygiene and Public Health, Johns Hopkins University, until 1999.

In 1993, Dr. Zilinskas was appointed William Foster Fellow at the U.S. Arms Control and Disarmament Agency (ACDA), where he worked on biological and toxin warfare issues. In 1994, ACDA seconded Dr. Zilinskas to the United Nations Special Commission (UNSCOM), where he worked as a biological analyst for seven months. He participated in two biological warfare-related inspections in Iraq (June and October 1994) encompassing 61 biological research and production facilities. He set up a database containing data about key dual-use biological equipment in Iraq and developed a protocol for UNSCOM's on-going monitoring and verification program in the biological field.

After the fellowship, Dr. Zilinskas returned to the UMBI and Johns Hopkins University. In addition, he continued to serve as a long-term consultant to ACDA (now part of the U.S. Department of State), for which he carried out studies on Cuban allegations of U.S. biological attacks against its people, animals, and plants and investigations carried out by the United Nations of chemical warfare in Southeast Asia and the Arabian Gulf region. Dr. Zilinskas also is a consultant to the U.S. Department of Defense.

In September 1998, Dr. Zilinskas was appointed Senior Scientist at the Center for Nonproliferation Studies (CNS), Monterey Institute of International Studies. On September 1, 2002, he was promoted to the Director of the Chemical and Biological Weapons Nonproliferation Program at the CNS. His research focuses on achieving effective biological arms control, assessing the proliferation potential of the former Soviet Union's biological warfare program, and meeting the threat of bioterrorism. Dr. Zilinskas' book Biological Warfare: Modern Offense and Defense, a definitive account on how modern biotechnology has qualitatively changed developments related to biological weapons and defense, was published in 1999. In 2005, the important reference work Encyclopedia of Bioterrorism Defense, which is co-edited by Richard Pilch and Dr. Zilinskas, was published by Wiley. He currently is writing a book on the former Soviet Union's biological warfare program, including its history, organization, accomplishments, and proliferation potential, which will be published in 2006.

Despite the increasing centrality of computer software in modern weapons systems, computing remains relatively underrepresented in public debates about weapons policy. For example, in 1991, a software glitch in the Patriot missile defense system killed 28 people, yet physicists remain the most prominent technical critics of this system. This talk suggests that the different patterns of political intervention exhibited by physicists and computer experts cannot be explained by technical relevance. It suggests alternate explanations by examining the processes by which technical judgments are generated and rendered authoritative in the political arena, using insights from science and technology studies. These processes are then illustrated by comparing how computer experts and physicists intervened in political controversy about the feasibility of 'Star Wars', President Ronald Reagan's proposal to develop a missile defense that would render the massive Soviet nuclear arsenal 'impotent and obsolete.' I compare how critical groups of physicists and computer professionals attempted to persuade the public that a perfect missile shield could not be built. This analysis suggests that sharp differences in the two groups' technical frames of analysis, rhetoric, and professional organizations all contributed to the physicists' ability to demonstrate a much higher level of consensus and authority in the political arena.

When the Soviet Union dissolved on Dec. 25, 1991, the nuclear threat changed from the Cold War concern of ending civilization as we know it to one of securing "loose nukes" in chaotic Russia and other states of the former Soviet Union. I had the opportunity to visit the secret cities of the Russian nuclear complex six weeks after the collapse and to initiate a program of scientific collaboration between U.S. and Russian nuclear scientists. Together, we made remarkable progress in reducing the threat in the early and mid-1990's because of the trust we were able to build based on mutual respect, similar objectives, and a common heritage in the great early-20th century school of European physics.

Although the number of joint U.S. - Russian cooperative threat reduction programs increased and the U.S. funding rose dramatically at the turn of the millennium, real progress slowed as U.S. and Russian objectives began to diverge, and the programs became politicized and bureaucratized. Major opportunities to reduce the long-term threat were lost. Cooperation was re-energized by the tragic events of 9/11 and the emerging threat of nuclear terrorism. Today, both Presidents Bush and Putin agree that keeping nuclear weapons out of the hands of terrorists is their highest security priority. Yet, strategy and commitment on both sides appear incommensurate with the threat. I will discuss critical barriers to and opportunities for renewed cooperation to meet the threat.

Siegfried S. Hecker is currently a Senior Fellow at the Los Alamos National Laboratory. Dr. Hecker was Director of Los Alamos National Laboratory from 1986-1997. He joined the Laboratory as technical staff member of the Physical Metallurgy Group in 1973, following a postdoctoral assignment there in 1968-1970 and a summer graduate student assignment in 1965. He served as Chairman of the Center for Materials Science and Division Leader of the Materials Science and Technology Division before becoming Director. From 1970 to 1973 he was a senior research metallurgist with the General Motors Research Laboratories.

Dr. Hecker received his B.S. in metallurgy in 1965 and M.S. in metallurgy in 1967 from Case Institute of Technology and his Ph.D. in metallurgy in 1968 from Case Western Reserve University.

Dr. Hecker is a member of the National Academy of Engineering, Foreign Member of the Russian Academy of Sciences, Fellow of the TMS (Minerals, Metallurgy and Materials Society), Fellow of the American Society for Metals, Honorary Member of the American Ceramics Society, and Fellow of the American Academy of Arts and Sciences. Among other awards, Dr. Hecker received the American Nuclear Society Seaborg Medal (2004), the Acta Materialia J. Herbert Hollomon Award (2004), the Case Western Reserve University Alumni Association Gold Medal (2004) and Undergraduate Distinguished Alumni Award (2001), the New Mexico Distinguished Public Service Award, (1998); was named Laboratory Director of the Year by the Federal Laboratory Consortium, (1998); received an honorary Doctor of Science degree (Honoris Causa) from Case Western Reserve University (1998); received the Department of Energy's Distinguished Associate Award, (1997); the University of California's President's Medal, (1997); the ASM Distinguished Life Membership Award, (1997); an Honorary Degree of Scientiae Doctoris, Ripon College (1997); the Navy League New York Council Roosevelt Gold Medal for Science (1996); the Aviation Week Group Laurels Award for National Security (1995); the James O. Douglas Gold Medal Award (1990); the ASM International's Distinguished Lectureship in Materials and Society, (1989); the Kent Van Horn Distinguished Alumnus Award, Case Western Reserve University (1989); an Honorary Degree of Scientiae Doctoris, College of Santa Fe, (1988); the Year's Top 100 Innovations Award from Science Digest (1985); the Department of Energy's E. O. Lawrence Award, (1984); the American Society for Metals, Marcus A. Grossman Young Author Award (1976); and the Wesley P. Sykes Outstanding Metallurgist Award, Case Institute of Technology (1965). He is a member of the American Association for the Advancement of Science, Council on Foreign Relations, Tau Beta Pi Honorary Engineering Fraternity, Alpha Sigma Mu Honorary Metallurgical Fraternity, and the Society of Sigma Xi.

In addition to his current research activities in plutonium science and stockpile stewardship, he works closely with the Russian Academy of Sciences and the Russian Ministry of Atomic Energy on a variety of cooperative threat reduction programs. Dr. Hecker is also actively involved with the U.S. National Academies, serving on the Council of the National Academy of Engineering, serving as chair of the newly established Committee on Counterterrorism Challenges for Russia and the United States, and as a member of the National Academies Committee on Nuclear Nonproliferation. He is a member of ASM International and TMS, the Minerals/Metals/Materials Society, having served both in numerous local and national positions, and a member of the Materials Research Society and the American Association for the Advancement of Science. He is a member of the Council on Foreign Relations and the Pacific Council. He serves on the Corporate Advisory Panel of the UK Atomic Weapons Establishment, is a member of the Advisory Group to the Cooperative Research and Development Foundation (CRDF), and previously served on the Board of Regents for the University of New Mexico.

Dr. Sarah Mendelson is a senior fellow with the Russia and Eurasia Program at the Center for Strategic and International Studies. Before joining CSIS in 2001, she taught international politics at the Fletcher School of Law and Diplomacy, Tufts University. Dr. Mendelson received her B.A. in history from Yale University, and her Ph.D. in political science from Columbia University. She also earned a certificate from the Harriman Institute.

At CSIS, she manages several projects that explore the links between security and human rights. Her current research includes collaborative work on public opinion surveys of Russian attitudes on democracy, human rights, Chechnya and the military. She directed a collaborative study evaluating the impact of Western democracy assistance to Eastern Europe and Eurasia. In addition, she has served on the staff of the National Democratic Institute's Moscow office, and was a resident associate at the Carnegie Endowment for International Peace. She has also been a fellow at CISAC and at Princeton University's Center of International Studies.

Dr. Mendelson serves on the steering committee of Human Rights Watch, the editorial board of International Security, and is a member of the Council on Foreign Relations, and the Program on New Approaches to Russian Security.