Months after winning the Nobel Prize, Lederberg arrived at the Stanford University School of Medicine to become the chair of genetics in 1959, after leaving his post at the University of Wisconsin. He led Stanford’s genetics department at a time when the medical school earned a reputation for research, until he left in 1978 to become president of The Rockefeller University in New York until 1990.

Lederberg shared the Nobel Prize in Physiology or Medicine with Edward Tatum and George Beadle. His portion of the prize came from his discovery that bacteria transfer genetic information, overturning the prevailing thought that bacteria weren’t able to swap DNA. Lederberg found that bacteria exchange loops of DNA called plasmids that allow bacteria to pick up new genes, and thereby adapt to new environments. The process Lederberg discovered has become a standard way for researchers to transfer genetic information between bacteria in the lab, and changed how researchers thought about infectious disease. It also laid the foundation for modern molecular biology, genetic engineering and biotechnology.

“Dr. Josh Lederberg was one of the greatest scientists of the 20th century with staggering achievements from virology and microbiology to genetics and planetary exploration,” said Philip Pizzo, MD, dean of the Stanford School of Medicine. “He was not only a world-renowned scientist but also an advocate on science and public policy. His impact on Stanford can be felt to this day and will surely continue long into the future.”

Lederberg was only 33 when he came to Stanford, but he already had a long research career that began in high school.

His father was a rabbi, and when Lederberg was a teen he promised to aid humanity through science rather than faith. He began doing independent research at the science-focused Stuyvesant High School, then continued that research as an undergraduate student at Columbia College. After starting medical school at Columbia University’s College of Physicians and Surgeons he left after two years to pursue a PhD at Yale, working with Tatum and Beadle on studies that led to their shared Nobel.

The year Lederberg arrived to head Stanford’s genetics department was a pivotal one in the medical school’s history. The school was in the process of moving from San Francisco to join the Stanford campus in Palo Alto. During that same time period Arthur Kornberg, PhD, who went on to win the 1959 Nobel Prize in Biochemistry, arrived to found Stanford’s biochemistry department. The departments led by Kornberg and Lederberg helped establish the medical school as a leader in biomedical research.

One of Lederberg’s first recruits to the new department was Leonard Herzenberg, PhD, emeritus professor of genetics, who went on to develop the fluorescence-activated cell sorting machine that opened up new areas of biological research. Herzenberg said Lederberg was supportive of his work without being dominating. “Josh was important for my life and for my career and made possible the development of the FACS,” he said.

Richard Myers, PhD, professor and the current chair of Stanford’s genetics department, called Lederberg a visionary. He said Lederberg recognized the importance of human genetics in a time when few people worked in that field. “That’s how Stanford became well-known in human and population genetics early on before it was really popular,” Myers said.

In addition to his scientific skills, Myers said he respected Lederberg for his diverse interests and generous personality. “He was extremely warm and interesting,” he said.

Throughout his career Lederberg had interests that strayed far from the laboratory bench. The launch of Sputnik in 1957 led Lederberg toward an interest in astronomy that lasted 20 years. His concern about the risk of spacecraft returning to Earth with contaminants from space resulted in a quarantine for space travel that remains in effect today. He went on to design experiments intended to detect the presence of life on Mars, resulting in the Mars Viking lander.

Early on, Lederberg recognized genetics as an information science and became increasingly aware of the value of computers. He formed collaborations with researchers at Stanford to create DENDRAL, a prototype artificial intelligence program for analyzing mass-spectrometric data of molecular structures, which led to further programs for disease diagnosis and management.

These wide-ranging interests were a hallmark of Lederberg’s intellect, according to Paul Berg, PhD, emeritus professor of biochemistry and Nobel Prize winner. “What was extraordinary is that he was at home in so many areas,” Berg said. “He made one of the really major discoveries that paved the way for modern genetics, but then he ventured into areas that were entirely different.”

Lederberg stayed true to his teenage promise to aid mankind. Concerned about the public’s awareness of science, he wrote a weekly science column in the Washington Post from 1966-71. Among the topics he addressed were infectious disease outbreaks and biological weapons, both of which were interests that he also pursued through his academic work. He served on national committees for biological weapons and became a national arms control advisor. These interests also led to collaborations with Stanford political scientists and physicists, which eventually resulted in the creation of an undergraduate curriculum in national security and arms control.

Lederberg left Stanford in 1978 to become president of The Rockefeller University. While there, he continued his research and, despite retirement in 1990, continued to work internationally to prevent the use of biological weapons, also serving on the executive committee and as a consulting professor at Stanford’s Center for International Security and Cooperation (CISAC).

Over the course of his life, Lederberg was elected to the National Academy of Sciences, the Institute of Medicine, received the Presidential Medal of Freedom and the National Medal of Science, was named an honorary life member of the New York Academy of Sciences, was awarded Foreign Membership of the Royal Society of London and holds the title of Commandeur, L’ordre des arts et des lettres in France.

Lederberg is survived by his wife Marguerite Stein Lederberg, PhD, his son David Kirsch and his daughter Anne Lederberg, and two grandchildren. Funeral services were held Feb. 5.

Steven E. Koonin, chief scientist for BP in London, gave an address titled "Energy, Environment, Security: Can We Have It All?" at 4 p.m. Monday, Feb. 4, in the Frances C. Arrillaga Alumni Center.

The talk, free and open to the public, was this year's Drell Lecture, hosted by Stanford's Center for International Security and Cooperation in the Freeman Spogli Institute for International Studies.

In 2004, Koonin joined BP, one of the world's largest energy companies, as group chief scientist. He is responsible for the company's long-range technology plans and activities, particularly those "beyond petroleum." His purview also includes BP's major university research programs around the world, and he provides technical advice to BP's senior executives.

The annual Drell Lecture, named for CISAC co-founder Sidney Drell, professor emeritus at the Stanford Linear Accelerator Center, and endowed by Albert and Cicely Wheelon, traditionally addresses a current, critical national or international security issue with important scientific or technical dimensions. Previous Drell lecturers have included New York Times correspondent Thom Shanker; the Rev. J. Bryan Hehir, a Harvard professor; Mohamed ElBaradei, director-general of the International Atomic Energy Agency; physician Margaret Hamburg; astronaut and Stanford alumna Sally Ride; and physicist Freeman Dyson.

Martha Crenshaw is a pioneer in terrorism studies, one of a handful of scholars worldwide who started investigating the subject long before Sept. 11, 2001.

Crenshaw, who joined CISAC this year as a senior fellow at FSI and a political science professor by courtesy, brings three decades of study to her current agenda of examining distinctions between so-called old and new terrorism, how terrorism ends, and why the United States is the target of terrorism.

"We are very fortunate to have Martha Crenshaw join CISAC as a senior fellow," said Scott Sagan, CISAC co-director. "Her detailed knowledge of the inside workings of terrorist organizations and her deep understanding of earlier counter-terrorist campaigns have brought much-needed historical perspective to contemporary policy debates after 9/11."

Associate professor of law Mariano-Florentino Cuéllar, who led the search that resulted in Crenshaw's hiring, said her "combination of attention to historical detail, interdisciplinary methods, and knowledge of institutional context has made her one of the nation's foremost scholars of terrorism. Her appointment is great news for CISAC and Stanford, where she will strengthen an already significant scholarly community working on homeland security and terrorism."

Coming to Stanford from Wesleyan University, where she was the Colin and Nancy Campbell Professor of Global Issues and Democratic Thought and a government professor, Crenshaw said she found the opportunity to join an interdisciplinary research center a welcome change.

"CISAC's and my interests merged perfectly," she said, as the center was looking to build its research expertise in terrorism. She said she looks forward to teaching graduate students in the Ford Dorsey Program in International Policy Studies as well as working with research colleagues at CISAC and across campus.

Crenshaw's terrorism studies began with a graduate seminar paper she wrote on actions by the FLN, or National Liberation Front, during Algeria's war for independence from France in the 1950s and 60s. She arrived at the topic the way many professors advise students to do--she noted in a study of Vietnam-era guerrilla warfare the comment that "no one has studied terrorism."

That seminar paper inspired her dissertation, which formed the basis of her 1978 book, Revolutionary Terrorism: The FLN in Algeria, 1954-1962, a case study in the strategic use of terrorism by a revolutionary nationalist movement.

Having written numerous articles and edited four books on terrorism, Crenshaw is now editing a book tentatively titled The Consequences of Counterterrorist Policies in Democracies. The Russell Sage Foundation supported the research, which Crenshaw said illuminates issues such as "the strength of executive power, effects of counterterrorism legislation on minorities, and unintended consequences of counterterrorism policies."

As a lead investigator with the National Consortium for the Study of Terrorism and Responses to Terrorism at the University of Maryland, a Department of Homeland Security Center of Excellence, Crenshaw is also researching why the United States is the target of terrorism, a study that could be especially useful in informing counterterrorism policy.

Crenshaw "trace[s] the evolution of anti-American terrorism over time--since the mid-1960s," she said, comparing groups that used terrorism to others with similar ideas that have not resorted to terrorism. Comparing case studies, she explained, allows her to "analyze incentives for the use of terrorism."

In "The Debate over 'New' versus 'Old' Terrorism," a paper Crenshaw presented at the American Political Science Association annual meeting in September--and which will be published as a chapter in an edited volume, she questions oft-heard claims that terrorism in recent years has taken on a new character to become more religious and lethal. She found the distinctions too hastily drawn and possibly dangerous.

"There is no fundamental difference between 'old' and 'new' terrorism," she said.

"Rejecting our accumulated knowledge of terrorism by dismissing it as 'obsolete'" would be a mistake that could lead to bad policy choices, she added. Before 9/ll, assumptions that "new" terrorism would forsake the "old" technique of hijacking and turn to weapons of mass destruction turned out to be wrong, she pointed out.

Crenshaw said researchers and policymakers should "ask why some groups cause large numbers of civilian casualties and others do not, rather than assuming that religious beliefs are the explanation for lethality."