May 2005 opened with a bleak couple of weeks for the nuclear Non-Proliferation Treaty (NPT). Delegates from 189 countries struggled to settle on an agenda for the seventh 5-year review of the Treaty, North Korea announced a new extraction of plutonium from its reactor to make nuclear weapons, and Iran stood firm against European attempts to dissuade it from pursuing a nuclear energy program that could be diverted for weapons-making. Yet CISAC's George Bunn, in an interview with BBC's "The World," cautioned against despair.

As the first general counsel to the U.S. Arms Control and Disarmament Agency, Bunn has watched the NPT weather many diplomatic storms since it entered into force in 1970. Far from a failure, the treaty prevented nuclear weapons from becoming a commonplace in nations' defense programs, he said.

"I think that if there were no NPT, there would be something like 35 to 40 countries with nuclear weapons," Bunn explained. "When you think that at the time of our negotiations in the 60s, Sweden and Switzerland both had programs to explore the possibility of making nuclear weapons"--ambitions that the NPT helped dissuade--the treaty has provided incalculable benefits to world security. "If Sweden and Switzerland had nuclear weapons, think how many other countries would have them," he added.

Today the treaty's main weakness is its focus on states' possession of nuclear weapons, at a time when terrorists' ambitions to acquire the weapons is a major concern. At the treaty's outset, "terrorism wasn't perceived by us as a threat. The treaty hardly deals with the threat of terrorism," Bunn said.

The radio interview with George Bunn and his son Matthew Bunn, also a nuclear arms expert, is available at the link below. (Windows Media Player is required.)

Of the Pentagon's $419.3 billion budget request for next year, only about $10.5 billion - 2 percent - will go toward basic research, applied research and advanced technology development. This represents a 20 percent reduction from last year, a drastic cutback that threatens the long-term security of the nation. Secretary of Defense Donald Rumsfeld should reconsider this request, and if he does not, Congress should restore the cut.

These research and development activities, known as the "technology base" program, are a vital part of the United States defense program. For good reason: the tech base is America's investment in the future. Over the years, tech base activities have yielded advances in scientific and engineering knowledge that have given United States forces the technological superiority that is responsible in large measure for their current dominance in conventional military power.

Research into basic understanding of methods for reducing radar signatures in the 1970's, for example, gave rise to "stealth" technology. Advances in electronic sensor technology enable the vast collection of information from satellites, and past work on computer systems permits distribution of this information in near real-time to military commanders. The combination of near-real-time intelligence and precision munitions are the heart of the so-called "revolution in military affairs" that avoids large and costly systems and approaches.

These advances require years of sustained effort by university, industry and government researchers. If the Pentagon does not make the required investments today, America will not have dominant military technology tomorrow.

The technology base program has also had a major effect on American industry. Indeed, it is the primary reason that the United States leads the world today in information technology. American companies not only draw heavily on the Pentagon's work, but they have also come to depend on it. The research and development programs of many of America's major information technology companies are almost exclusively devoted to product development.

It was the investment of the Defense Advanced Research Projects Agency in a network known as ARPA-net in the 1960's and 70's, for example, that gave rise to the Internet. The JPEG file format for digital images is based on software and standards developed by the Pentagon. The global positioning satellite system, first developed for precision-guided munitions, is now used in many cellphones and has the potential to revolutionize our air traffic control system. America's ability to translate the Pentagon's technology base into commercial achievement is the envy of the world.

Of course, the administration and Congress need to make tough budget choices. But to shift money away from the technology base to pay for Iraq, other current military operations or research on large, expensive initiatives, is to give priority to the near term at the expense of the future. This is doubtful judgment, especially at a time when the nature of the threat confronting America is changing. New threats, like catastrophic terrorism and the spread of weapons of mass destruction, urgently call for new technology.

There should be no doubt that basic research will continue to make a contribution. Robotics, artificial intelligence, biotechnology, brain and cognitive sciences, nanotechnology, large-scale modeling and simulation: all these fields can have a huge impact. If properly supported, basic technology work is likely to lead to unprecedented results.

Mr. Rumsfeld has long championed the need to transform the military and exploit new technology. He has supported the technology base in the past and has urged the adoption of a more long-term view of security needs. He should, then, be willing to review and reverse the Pentagon's request for reducing its technology base. He should understand that short-term budget requirements for the armed services always tend to push out the technology base program - unless the Pentagon leadership supports it.

Perhaps the reason for this year's reduction is the mistaken belief that a one-year gap in financing does not matter, because innovation takes so long. But tech base advances occur because of stable financing. Fluctuating budgets cause wasted effort.

It is possible that Congress will restore the cuts in technology base programs and correspondingly reduce some other part of the defense budget. But Mr. Rumsfeld should not depend on Congress. It would be vastly better if the Pentagon understood the importance of the tech base effort, and acted on that understanding.

The Department of Defense's technology base programs have been an important factor in giving America the dominant military force in the world. They have also helped many American information technology companies become successful. The Pentagon should maintain its dedication to these programs, and that will require leadership from the secretary of defense - as well as support from Congress.

John Deutch, a professor of chemistry at M.I.T., was deputy secretary of defense from 1994 to 1995. William J. Perry was secretary of defense from 1994 to 1997.

The nine nations that possess nuclear weapons have enough plutonium and high-enriched uranium collectively to build more than 100,000 additional nuclear weapons, according to a new report aimed at controlling the spread of such weapons and the materials to make them.

This considerable surplus of nuclear-explosive, or fissile, materials threatens global security, as other nations or terrorists seek the means to build nuclear weapons. "Despite a compelling security requirement to keep nuclear weapons out of the hands of terrorists and additional countries," the report warns, "not nearly enough is being done today to achieve this objective."

A group of 23 nuclear experts, convened by Stanford University's Center for International Security and Cooperation (CISAC) and Princeton University's Program on Science and Global Security (PS&GS), issued the report, "Preventing Nuclear Proliferation and Nuclear Terrorism: Essential Steps to Reduce the Availability of Nuclear-Explosive Materials."

The report details which nations currently have the means to produce nuclear weapons and how much fissile material they possess. "This distribution of fissile material defines the critical tasks facing the international community," the report states. It calls for nations to cooperate on seven steps.

At the top of the report's "to-do list for the international community" is closing what some see as a gaping loophole in the nuclear Non-Proliferation Treaty (NPT)--the ability of a nation to acquire nuclear weapons capabilities and then withdraw from the NPT without penalty. So the report first proposes that the U.N. Security Council establish sanctions to impose against any country that withdraws from the NPT and attempts to build weapons using fissile materials and facilities obtained under the treaty for ostensibly peaceful purposes.

The NPT, in effect since 1970, will undergo its seventh 5-year review by more than 180 member states May 2-27 in New York. The report, issued in time for this review, recommends six additional steps for consideration by the conference delegates and other nuclear nonproliferation specialists:

-- "strengthen international physical security standards;

-- "stop the uncontrolled spread of uranium enrichment plants," and "subject all enrichment plants to an extra layer of multinational monitoring;"

-- declare a moratorium on building new plants to reprocess spent nuclear fuel that could be diverted to weapons production;

-- "conclude a verified global treaty ending all further production of fissile materials for weapons;

-- "dispose of much more of the excess fissile materials recovered from dismantled Cold War weapons; and

-- "phase out the use of high-enriched uranium (HEU) as a reactor fuel," in favor of low-enriched uranium, which cannot be made into nuclear weapons without further enrichment.

Some of the study group's recommendations "have been on the international agenda for decades," the report points out, but "most are barely moving forward, if not completely stalled. These measures urgently need high-level attention."

"All of the report's proposals focus on weapons-usable fissile materials--highly enriched uranium and plutonium--because they are the essential materials for nuclear weapons," said CISAC Co-Director Christopher F. Chyba, who led the study with PS&GS Co-Directors Harold Feiveson and Frank von Hippel. "They and the technologies to produce them must be much more strictly controlled if further nuclear proliferation and nuclear terrorism are to be prevented. The report lays out a series of steps to do so," Chyba added.

The researchers intended to strengthen similar proposals under discussion. The report "gives technical details and support to policy ideas on the control of nuclear explosive materials and their means of production that Mohamed ElBaradei (director-general of the International Atomic Energy Agency) and others have been forwarding," explained Feiveson.

While the report emphasizes physical security measures geared toward reducing the supply of nuclear weapons materials, its authors acknowledge that "demand-side measures" are "equally important." A comprehensive strategy to halt nuclear proliferation must also "address the reasons that certain states choose to pursue nuclear weapons," the report states.

The research group of scientists, political scientists, and international legal experts from leading research and regulatory institutions met at Stanford University in August 2003 to begin their assessment of the global stock of nuclear weapons and the nuclear-explosive materials needed to make them and to outline a plan for limiting the spread of these materials. They continued to refine their recommendations, to produce their report in time for this year's NPT review.

By Dawn Levy

Responding to a terrorist attack employing biological or chemical agents requires knowledge spanning many disciplines. Three Stanford researchers were among nearly 135 leading scientists and technical experts from industry, academia and government invited to participate in the Gordon Research Conference on Chemical and Biological Terrorism Jan. 30-Feb. 4 in Buellton, Calif. The conference brought together public and private sectors to discuss what has worked, where problems are now and may appear in the future, and what needs more attention in responding to and preventing terrorism. The goal was to move toward a better "systems approach" to defense.

The Stanford participants were Margaret E. Kosal, a science fellow at the Center for International Security and Cooperation (CISAC) with a doctorate in chemistry; Steven M. Block, a professor of applied physics and of biological sciences and senior fellow, by courtesy, at the Stanford Institute for International Studies; and Mark A. Musen, a professor of medicine (medical informatics) and, by courtesy, of computer science.

The conference included discussions of public health surveillance and response, food supply vulnerabilities and agricultural security, forensics of biological and chemical evidence, and the changing nature of the threat environment.

Both biological and chemical terrorist attacks have the potential to cause a large number of causalities and overwhelm medical capabilities, or "surge capacity." The nation's terrorism defense plans focus on mass-effect bioterrorism--events with the potential to infect tens of thousands and kill more than a thousand. But those plans may not effectively counter small-scale biological or chemical attacks, much less nuclear or radiological attacks, Kosal asserted.

Musen spoke about the computational problems of automating surveillance for possible bioterrorism using "prediagnostic" indicators that become available even before health-care workers can identify a specific epidemic.

"There is enormous enthusiasm--and enormous spending--for combining databases of over-the-counter drug sales, absenteeism records, 911 calls and admitting diagnoses to emergency rooms and clinics," he said. "There has been virtually no empirical evaluation of any of these efforts, despite all the excitement."

Musen discussed difficulties computers have making sense of high-volume, low-signal data streams, including basic problems with the way that the data typically are represented, difficulties of integrating disparate data sources and uncertainty in how to present the results of computational analyses to public-health officials in an optimal way.

"Although there is enormous political pressure to be 'doing something' to monitor for bioterrorism, it's also important to take a step back and to engage in the research needed to determine what we really should be doing," Musen said.

Chemical threats are underestimated

The focus on bioterror threats may miss a more frequent occurrence--chemical attacks. In a presentation titled "The Shifting Face of Chemical Terrorism: Assessing an Emerging Threat," Kosal examined the growing trend of non-state actors to use improvised chemical devices (ICDs) that may include choking and blistering agents.

"The path from the 'street chemistry' of improvised explosive devices [IEDs] to ICDs incorporating commercial chemicals is very short, whereas the path from IEDs to transgenic biological agents effectively weaponized is a substantial leap for states and even more so for terrorists," Kosal said. "While U.S. policy is focused on defending against a mass-effect bioterrorism attack, we may be missing a lower-tech threat of much higher probability."

Half of the U.S. fatalities in Iraq have been due to IEDs, typically roadside bombs, Kosal said. "This strongly suggests there is a substantial tacit knowledge base and readily available materials for constructing these types of weapons--one guy has not been making them all in a Mosul garage." While incorporating chemicals into roadside bombs would not dramatically increase military casualties, incorporating them in devices employed in enclosed spaces could, Kosal said.

An analysis of terrorism between 1910 and 2003 from open-source information shows the lion's share of 265 terrorist attacks--76 percent--were chemical. Only 17 percent were biological, 0 percent nuclear (involving fissile material, such as that powering an atomic bomb) and 7 percent radiological (involving radioactive elements that cannot be used for fission or that contain less than a critical mass of fissionable material, such as those employed in "dirty bombs").

It used to be that the major threat of chemical weapons came from state-based programs. Chlorine and mustard gases were used extensively in World War I, for example. The United States and the former Soviet Union amassed stockpiles exceeding 40,000 tons, which are still being destroyed. International efforts to control the exchange of certain chemicals, such as precursors for nerve and blister agents, have been effective. Kosal cited the refusal in the 1980s during the Iran-Iraq war of the world community to sell Iraq the key precursor to mustard gas.

Nowadays, terrorists both foreign and domestic may disperse traditional chemical warfare agents using improvised methods. In 1995, for example, the Aum Shinrikyo group crudely dispersed a nerve agent in a Tokyo subway--killing 12 and panicking thousands--using umbrellas to puncture 11 garbage bags, each filled with a common solvent and about a pound of sarin. Today's chemical weapons may just as likely come from common commercial sources, such as agrochemicals. Radical Islamists have even attempted to weaponize a research chemical, osmium tetroxide, used to prepare biological specimens for electron microscopy.

In contrast with nuclear or mass-effect biological weapons, chemical weapons may not require sophisticated knowledge to produce. In 2003 at a rented storage space in Tyler, Texas, government agents seized half a million rounds of ammunition, more than 60 pipe bombs, remote-controlled bombs disguised as briefcases, pamphlets on how to make chemical weapons and improvised hydrogen cyanide dispersal devices hypothetically capable of killing thousands in a minute. The stockpiler, William J. Krar, described as a white supremacist and anti-government extremist, was sentenced to 11 years in federal prison. His specific objectives remain unknown to authorities.

Kosal said terrorists do not appear to be concocting new chemicals; they're co-opting existing ones. "Chemical terrorism is likely to be a crime of opportunity and familiarity with chemicals and chemistry," Kosal said. "Perhaps the basic knowledge and materials--commercial dual-use chemicals in this instance--are too globally widespread to justify efforts to control the capability of terrorists to co-opt them for malfeasant uses. . . . The best threat-reduction policy may be to reduce the motivation.

"Much of the academic and policy dialogue segregates the folks discussing motivation from the folks discussing capacity and vulnerability. The former tend to be historians and social scientists and the latter, biologists, chemists and physicists. It may prove that decreasing terrorist motivation is unfeasible in the near term, but here is an example where those with the technical knowledge and those with the social science knowledge need to be working cooperatively, the type of interaction that the CISAC Science Fellows program fosters," Kosal said.

Ten thousand fingers on the bioterror "button"

Block's talk focused on the growing threat of bioterror. While chemicals have killed more people to date than have biological weapons, future biological attacks using infectious, untreatable pathogens have the potential to kill more people than chemicals. Block wryly called such biological attacks "the gift that keeps on giving."

Block said post-9/11 restrictions aimed at keeping pathogens out of the wrong hands have backfired. One is the Department of Health and Human Services' "Select Agent Rule," which establishes requirements regarding possession and use in the United States, receipt from outside the United States and transfer within the United States of a particular list of agents and toxins.

"We're shooting ourselves in the foot," Block said. "We've made it so hard to work on these pathogens that even our so-called 'A-Team' can't do research with them." World-renowned plague researcher Stanley Falkow of Stanford and famed anthrax expert John Collier of Harvard have stopped working on live pathogens because of restrictive effects of recent legislation, according to Block. They now confine their research to a handful of cloned genes. "It's almost impossible to hire grad students or postdocs to work on Select Agents. Such research has been driven underground or into our national labs, which historically have not had the biological expertise found in the top academic labs and biotech companies."

Much of our response to bioterror threats is based on how we've historically responded to nuclear terror threats, Block said. "With nuclear weapons, only two things can be made to go 'boom'--plutonium and highly enriched uranium," he said. That made it comparatively easy to track and control materials, and to get a handle on the problem. "We tried to keep nuclear secrets secret. Not everyone knows how to make an atomic bomb."

In contrast, the genie has long been out of the bottle when it comes to biological agents. Virtually all research is reported in the open literature. "Even if we were to stop publishing everything now, there'd be enough public information to keep bioterrorists busy for at least another 50 years," he said.

"Back in the nuclear age, only a few countries were nuclear powers, and only a few people were authorized to have their 'fingers on the button,'" Block said. "Like them or not, they were responsible people. Contrast that with a world where genetically engineered weapons can be produced by, say, 10,000 people. Someone is guaranteed to press that button. We can't stop [bioterror acts] at the source any more than we can stop a computer virus at the source."

Rather than futilely attempting to thwart biological threats at their sources, which are ubiquitous, Block advocated shoring up the public health system so it can respond nimbly once threat turns to reality. A new generation of antitoxin, antiviral and antibacterial agents may mitigate ill effects, and improved vaccines may prevent damage altogether. "We need to work the problem from the other direction," he said. "To confine our attention to Select Agents alone is essentially putting on blinders. The future threats we may face may bear little relation to the organisms on the current list."