Bioterrorism
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Reuben W. Hills Conference Room

Graduate School of Business
Stanford University
Stanford, CA 94305-5015

(650) 724-1676 (650) 725-0468
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Jeffrey S. Skoll Professor of Management Science
CISAC Affiliated Faculty Member
Wein.jpg PhD

Lawrence Wein is the Jeffrey S. Skoll Professor of Management Science at the Graduate School of Business, Stanford University, and an affiliated faculty member at CISAC. After getting a PhD in Operations Research from Stanford University in 1988, he spent 14 years at the Sloan School of Management at MIT, where he was the DEC Leaders for Manufacturing Professor of Management Science. His research interests include mathematical models in operations management, medicine and biology.

Since 2001, he has analyzed a variety of homeland security problems. His homeland security work includes four papers in Proceedings of the National Academy of Sciences, on an emergency response to a smallpox attack, an emergency response to an anthrax attack, a biometric analysis of the US-VISIT Program, and an analysis of a bioterror attack on the milk supply. He has also published the Washington Post op-ed "Unready for Anthrax" (2003) and the New York Times op-ed "Got Toxic Milk?", and has written papers on port security, indoor remediation after an anthrax attack, and the detention and removal of illegal aliens.

For his homeland security research, Wein has received several awards from the International Federation of Operations Research and Management Science (INFORMS), including the Koopman Prize for the best paper in military operations research, the INFORMS Expository Writing Award, the INFORMS President’s Award for contributions to society, the Philip McCord Morse Lectureship, the Frederick W. Lanchester Prize for best research publication, and the George E. Kimball Medal. He was Editor-in-Chief of Operations Research from 2000 to 2005, and was elected to the National Academy of Engineering in 2009.   

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Lawrence M. Wein
Seminars

Graduate School of Business
Stanford University
Stanford, CA 94305-5015

(650) 724-1676 (650) 725-0468
0
Jeffrey S. Skoll Professor of Management Science
CISAC Affiliated Faculty Member
Wein.jpg PhD

Lawrence Wein is the Jeffrey S. Skoll Professor of Management Science at the Graduate School of Business, Stanford University, and an affiliated faculty member at CISAC. After getting a PhD in Operations Research from Stanford University in 1988, he spent 14 years at the Sloan School of Management at MIT, where he was the DEC Leaders for Manufacturing Professor of Management Science. His research interests include mathematical models in operations management, medicine and biology.

Since 2001, he has analyzed a variety of homeland security problems. His homeland security work includes four papers in Proceedings of the National Academy of Sciences, on an emergency response to a smallpox attack, an emergency response to an anthrax attack, a biometric analysis of the US-VISIT Program, and an analysis of a bioterror attack on the milk supply. He has also published the Washington Post op-ed "Unready for Anthrax" (2003) and the New York Times op-ed "Got Toxic Milk?", and has written papers on port security, indoor remediation after an anthrax attack, and the detention and removal of illegal aliens.

For his homeland security research, Wein has received several awards from the International Federation of Operations Research and Management Science (INFORMS), including the Koopman Prize for the best paper in military operations research, the INFORMS Expository Writing Award, the INFORMS President’s Award for contributions to society, the Philip McCord Morse Lectureship, the Frederick W. Lanchester Prize for best research publication, and the George E. Kimball Medal. He was Editor-in-Chief of Operations Research from 2000 to 2005, and was elected to the National Academy of Engineering in 2009.   

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Speaker's Biography: NA

Kresge Auditorium, Stanford University

Margaret Hamburg Vice President for Biological Programs Nuclear Threat Initiative
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STANFORD, Calif.— More than 100 hostages are dead after Russian authorities used an unidentified gas to incapacitate terrorists holding 750 people in a Moscow theater. Nearly all of the deaths were due to the gas, which Russian authorities have so far refused to identify.

Press coverage has rightly emphasized grief and the question of why antidotes were not immediately available. It has then focused on whether the Russians' use of gas was a violation of the 1997 Chemical Weapons Convention. But this focus, while important, risks overlooking the big picture when it comes to Russian chemical weapons.

The Chemical Weapons Convention is a global treaty with more than 170 signatory nations. It bans the production, acquisition, stockpiling, transfer and use of chemical weapons -- the first arms-control treaty to outlaw an entire class of so-called weapons of mass destruction. It also requires its signatories to declare and destroy, by certain deadlines, the chemical weapons they possess.

Since the 1925 Geneva Protocol prohibiting the use of chemical and biological weapons in war -- a reaction to gas attacks in World War I -- the world has struggled to ban these weapons. In part, this is because of their indiscriminate nature.

After Sept. 11, 2001, it seems all the more important to eliminate stocks of such weapons because access to them could confer such power to terrorists. In a world with 70,000 metric tons of chemical weapons agents, some of which may be vulnerable to terrorist theft, the verified elimination of these weapons will be a step toward greater security for all. This is true despite the disturbing fact that Iraq, North Korea and certain other nations are not parties to the convention.

The weapons convention permits the production and use of riot-control agents for law enforcement purposes. Until the Russians inform us of the agent used, whether they were in violation of the convention will remain uncertain. But renewed attention to Russian chemical agents should focus on a more important issue. Russia retains some 40,000 tons of chemical warfare blister agents and nerve gas. It is required by the convention to destroy them, and the United States and European nations have agreed to help. But American efforts under the Nunn-Lugar Cooperative Threat Reduction program are stalled in Congress.

The Cooperative Threat Reduction program began in 1992. It provides expertise and funding to help the former Soviet Union secure and destroy nuclear, chemical and biological weapons and materials. Progress with chemical and biological weapons has been especially slow, and the Russians have too often been less than forthcoming.

Of particular concern has been the Russian stockpile at Shchuch'ye, a town near the southern border with Kazakhstan. The Shchuch'ye stockpile contains nearly two million artillery shells -- and hundreds of missile warheads -- filled with nerve gas or other chemical weapons. Although stockpile security has been upgraded with help from American financing, the threat of insider theft remains real. Many of the shells are in working condition, and they are small and easily transportable.

Cooperative Threat Reduction funds have paid to design a plant for construction at Shchuch'ye to destroy these weapons securely and safely. The Pentagon wants $130 million for construction in the new fiscal year. Russia, its economy still weak, won't do this without American assistance. But the program is currently stalled in a Congressional conference committee due to a disagreement over granting the president authority to proceed with the project.

The Bush administration's new national security strategy has emphasized the destruction of weapons of mass destruction by pre-emptive strikes if necessary. But at Shchuch'ye alone, the United States could destroy more than 5,000 tons of ready-to-use weapons of mass destruction through a different kind of pre-emptive strike -- action by a Congressional committee.  

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New York Times
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The anthrax attacks in fall 2001, and the fear and confusion that followed, made it all too clear that the United States lacks a comprehensive strategy for coping with bioterrorism. For too long, thinking about biological weapons has been held hostage to misplaced analogies to nuclear or chemical weapons. An effective strategy must begin by focusing on the special challenges posed by biological threats.

Reprinted in R.D. Howard and R.L. Sawyer, eds., Terrorism and Counterterrorism: Understanding the New Security Environment (Guilford, CT: McGraw-Hill/Dushkin, 2002), pp. 174-184.

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Foreign Affairs
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The United States is in the midst of its third major debate on nationwide ballistic missile defense-the first culminating in the 1972 ABM Treaty and the second sparked by President Reagan's "Star Wars" speech in 1983. This time the Cold War is over, the objectives for the defense are limited, and technology has advanced to the point where some options may be technically feasible.

However, intercontinental ballistic missiles (ICBMs) are not the primary threat to the United States, as events since September 11 demonstrate. Other homeland defense programs, especially civil defenses against bioterrorism, are more important. Yet emerging missile states may acquire ICBMs some day. To the extent that this is a concern, diplomatic efforts can limit the spread of ballistic missiles, and deterrence can dissuade their use. National missile defense (NMD), then, is insurance against the relatively unlikely event that ICBMs will be launched against the United States.

If the United States decides to deploy a limited NMD, the questions become what type and how much? A midcourse NMD system (one that attempts to intercept missile warheads as they fall through outer space) of the sort proposed for deployment in Alaska is the most technically mature option and would probably work well enough against emerging ICBM threats to justify limited deployment, assuming that the threat materializes. However, such a defense should contain only about 20 interceptors to minimize adverse political reactions from Russia and China. Over the long run, midcourse defenses may be vulnerable to sophisticated countermeasures. Therefore, the United States should place greater emphasis on land, naval, and air-based boostphase intercept options (defenses that attempt to intercept the ballistic missile while its rocket motors are still burning) because they are more robust to countermeasures and they pose relatively little threat to Russia and China. Space-based boost-phase NMD systems have the advantage of global coverage; however, they are technically more challenging, probably more expensive, and more destabilizing.

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Issues in Science and Technology, American Academy of Arts and Sciences
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Cubberly Auditorium, School of Education, Stanford University

(650) 725-6501
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Michael and Barbara Berberian Professor (emeritus) at FSI and Engineering
rsd15_078_0380a.jpg MS, PhD

William Perry is the Michael and Barbara Berberian Professor (emeritus) at Stanford University. He is a senior fellow at the Freeman Spogli Institute and the Hoover Institution, and serves as director of the Preventive Defense Project. He is an expert in U.S. foreign policy, national security and arms control. He was the co-director of CISAC from 1988 to 1993, during which time he was also a part-time professor at Stanford. He was a part-time lecturer in the Department of Mathematics at Santa Clara University from 1971 to 1977.

Perry was the 19th secretary of defense for the United States, serving from February 1994 to January 1997. He previously served as deputy secretary of defense (1993-1994) and as under secretary of defense for research and engineering (1977-1981). Dr. Perry currently serves on the Defense Policy Board (DPB). He is on the board of directors of Covant and several emerging high-tech companies. His previous business experience includes serving as a laboratory director for General Telephone and Electronics (1954-1964); founder and president of ESL Inc. (1964-1977); executive vice-president of Hambrecht & Quist Inc. (1981-1985); and founder and chairman of Technology Strategies & Alliances (1985-1993). He is a member of the National Academy of Engineering and a fellow of the American Academy of Arts and Sciences.

From 1946 to 1947, Perry was an enlisted man in the Army Corps of Engineers, and served in the Army of Occupation in Japan. He joined the Reserve Officer Training Corps in 1948 and was a second lieutenant in the Army Reserves from 1950 to 1955. He was awarded the Presidential Medal of Freedom in 1997 and the Knight Commander of the British Empire in 1998. Perry has received a number of other awards including the Department of Defense Distinguished Service Medal (1980 and 1981), and Outstanding Civilian Service Medals from the Army (1962 and 1997), the Air Force (1997), the Navy (1997), the Defense Intelligence Agency (1977 and 1997), NASA (1981) and the Coast Guard (1997). He received the American Electronic Association's Medal of Achievement (1980), the Eisenhower Award (1996), the Marshall Award (1997), the Forrestal Medal (1994), and the Henry Stimson Medal (1994). The National Academy of Engineering selected him for the Arthur Bueche Medal in 1996. He has received awards from the enlisted personnel of the Army, Navy, and the Air Force. He has received decorations from the governments of Albania, Bahrain, France, Germany, Hungary, Japan, Korea, Poland, Slovenia, and Ukraine. He received a BS and MS from Stanford University and a PhD from Pennsylvania State University, all in mathematics.

Director of the Preventive Defense Project at CISAC
FSI Senior Fellow
CISAC Faculty Member
Not in Residence
Date Label
William Perry Former Secretary of Defense Moderator CISAC
George Fidas Deputy National Inteligence Officer for Global and Multilateral Issues Panelist National Intelligence Council
Margaret Hamburg Former Assistant Secretary of Health Panelist Nuclear Threat Initiative
James Hughes Director Panelist National Center for Infectious Diseases
Panel Discussions
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Many CISAC projects involve decision makers who have to respond to a threat quickly in spite of uncertain evidence that it is really there. Surprise attack, the stability of nuclear arsenals, monitoring an arms agreement, intervening against genocide, distinguishing epidemics from bioterrorism, and intercepting a dangerous asteroid -- these all require detecting a threat quickly but avoiding a false alarm. Most of our work has involved assembling and judging the evidence of the threat, but further issues arise around the next step: what to do given the evidence. These problems become more subtle when the decision is a "strategic" one, i.e., made against an adversary who knows you are watching. The talk will illustrate the use of game theory to come to some counterintuitive conclusions.

Reuben W. Hills Conference Room, Encina Hall East, 2nd floor

Barry O'Neill Visiting Fellow Speaker CISAC
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The official U.S. government policy is to maintain "calculated ambiguity" about whether the United States would retaliate with nuclear weapons in response to an adversary's use of chemical weapons (CW) or biological weapons (BW) against U.S. allies, U.S. armed forces overseas, or the U.S. homeland. Since the 1991 Gulf War, numerous civilian and military leaders have stated that the United States might use nuclear weapons in response to CW and BW threats or attacks, and some have even stated that the United States will use nuclear weapons in such circumstances. The central argument in my spring 2000 International Security article was that this policy has created a dangerous "commitment trap" problem.

The benefit of making such nuclear threats, whether stated ambiguously or clearly, is that they can increase an adversary's estimate of the probability that the U.S. president would order nuclear retaliation, which should therefore decrease the likelihood of chemical or biological weapons attacks. But there is a serious cost attached to this obvious benefit: If deterrence fails despite nuclear threats, the statements will also increase the likelihood that the United States will actually use nuclear weapons, because the president's personal and the U.S. government's institutional reputations for following through on threats would be perceived to be at stake.

I argued that current U.S. nuclear doctrine has therefore created a subtle dilemma that has not been recognized, much less debated, in both policy and academic circles: Is the improvement in the U.S. ability to deter CW and BW threats worth the increased likelihood of a U.S. nuclear response if deterrence fails?

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International Security
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Scott D. Sagan
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A biological terrorist attack probably would first be detected by doctors or other health-care workers. The speed of a response would then depend on their rapid recognition and communication that certain illnesses appeared out of the ordinary. For this reason, preparing for biological terrorism has more in common with confronting the threat of emerging infectious diseases than with preparing for chemical or nuclear attacks. Defense against bioterrorism, like protection against emerging diseases, must therefore rely on improved national and international public-health surveillance. Too often, thinking about bioterrorism has mimicked thinking about chemical terrorism, a confusion that leads to an emphasis on the wrong approaches in preparing to meet the threat.

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Survival
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