Water
-

Cellular prion protein (PrPC) is present in the healthy adult brain. It is a presumably essential membrane protein but its cellular function is unclear. Like Ice-9 - the fictitious water allotrope in Kurt Vonnegut's Cat's Cradle, which "taught the atoms a novel way in which to stack, lock and crystallize until the oceans turned to ice" - cellular prion protein can, in a rare event, adopt a pathogenic and 'contagious' shape, PrPSc, which causes mad cow disease or Bovine Spongiform Encephalopathy (BSE). New variant Creutzfeldt Jakob Disease (vCJD) is the human malady attributed to eating beef tainted with BSE. In comparison to the UK epidemic (at the peak of which 37,280 cases of BSE were reported in the single year 1992), the emergence of four North American mad cows since May 2003 is minor yet still alarming. This work examines the USDA's response to indigenous BSE as manifested in "The Final Rule" (9 CFR 93-96, Jan 4, 2005) and questions whether current regulations are stringent enough to keep PrPSc out of cattle feed and human food.

Sheila Healy is a CISAC Science Fellow. She is currently analyzing USDA policy addressing Bovine Spongiform Encephalopathy (BSE) or mad cow disease. She recently finished a postdoctoral appointment in Stanley Prusiner's laboratory in the Department of Neurology at the University of California, San Francisco. There she studied the molecular and structural requirements for the conversion of cellular prion protein to its pathogenic form, the agent that causes BSE. She holds a doctoral degree in biochemistry and molecular and cellular biology from the University of Arizona.

Reuben W. Hills Conference Room, East 207, Encina Hall

Sheila Healy
Seminars
Authors
News Type
Commentary
Date
Paragraphs
John W. Lewis is professor emeritus of Chinese politics at Stanford University's Center for International Security and Cooperation and a frequent visitor to China and North Korea. He wrote this for the Mercury News.

Beijing tries to read mixed U.S. signals in Korea diplomacy By John W. Lewis

For the past year China has led the quest for a negotiated solution to the Korean nuclear crisis. It facilitated and hosted three-way talks with the United States and North Korea a year ago this week and two sessions of the six-party talks (adding South Korea, Japan and Russia) in August and February. Its officials crisscrossed the globe to explore potential areas of common interest and compromise and this week hosted North Korean leader Kim Jong Il to explore options for the beleaguered Korean Peninsula. Yet, in each of the formal talks, the Chinese have been discouraged by the minimal results. They are now questioning U.S. intentions toward Korea and, in the longer term, toward China.

Beijing considers the unchecked expansion of North Korea's nuclear weapons to be a real possibility, and its reasoning starts with the record of U.S. policies toward nuclear proliferation. That record, the Chinese argue, is mixed and often contradictory. As a result, China worries that Washington might continue to tolerate the program so long as Pyongyang did not cross key red lines, such as the transfer of nuclear materials to terrorists.

Whatever Beijing's past position on nuclear matters, many senior Chinese now regard nuclear weapons on their border to be a direct threat to their national security and suspect Washington of downplaying that danger. For them, it is no great leap to the conclusion that the unfettered growth of the Korean program might embolden others in Asia, including Taiwan, to acquire nuclear weapons despite verbal opposition from Washington. Beijing's leaders can easily imagine how that nightmarish turn of events would undermine the nation's drive toward modernization and end strategic cooperation with the United States.

Despite the fact that all parties at the six-party meeting in February endorsed the dismantling of the North's nuclear weapons program, the Chinese fear that the talks may be dead in the water. Following that meeting, they began to debate other ways to resolve the crisis. They had already reorganized the leadership team responsible for North Korean affairs, and that team had begun acting to prevent the worst case, including offering further inducements to Kim Jong Il this week. Whereas last fall the talk of deepening U.S.-China cooperation on Korea pervaded the news, now, especially after Vice President Dick Cheney's uncompromising stand on Korea and Taiwan last week, the reverse is occurring.

What China can do in these circumstances is quite limited. Its influence on North Korea is largely determined by what the United States does or doesn't do. By refusing to negotiate on a staged process leading to the eventual dismantlement of Pyongyang's nuclear weapons, Washington has tacitly allowed the North's program to proceed. It has rejected proposals for a temporary freeze, technical talks and any interim steps short of the unconditional and complete ending of the program. The result is virtual paralysis.

Beijing has been able to work with North Korea only when it could find areas of potential compromise between Washington and Pyongyang. It cannot or will not act

alone to exert pressure because this would jeopardize its influence on the North. Contrary to a widely circulated story, Beijing did not cut off energy shipments to North Korea for three days in 2003. Beijing would not take such a counterproductive action when its main influence with the North lies in the kind of quiet diplomacy being practiced this week with Kim Jong Il.

Many in Beijing are beginning to question whether there might be a more promising approach with Pyongyang. Should the Chinese, South Koreans and Russians conclude that making progress toward the common goal of the North's complete nuclear disarmament is out of reach, for example, they reluctantly might translate their joint offer of aid in February into a quid pro quo for a partial agreement, such as a limited freeze, that would allow the situation to stabilize. China could worry that such an independent action could endanger the common front with Washington. At the same time, it could calculate that the United States would be sufficiently pleased with any solution that halted the North Korean nuclear program.

None of these developments may come to pass, of course, but who could have imagined a year ago that Washington would have permitted the situation to deteriorate to the present point?

All News button
1
Paragraphs

Published in conjunction with the Georgia Tech Information Security Center (GTISC), Georgia Institute of Technology.

From the Introduction:
"The election of the Bharatiya Janata Party (BJP) in 1997 signaled renewed interest in IT and the Internet. The BJP advocated economic liberalization and listed IT as one of the government's top five priorities, along with more traditional issues such as the provision of potable drinking water and education [10]. "Indian IT has had many small voices, but the BJP is attempting to give IT a national voice" [10]. In May 1998, Prime Minister Vajpayee organized a national IT task force to make recommendations for a comprehensive policy overhaul. The task force's recommendations were instrumental in initiating wide-ranging and fundamental changes in Indian IT policy.

The speed with which the Indian National Task Force on Information Technology and Software Development moved was indicative of the changing government attitude. Within 90 days of its establishment, the Task Force produced an extensive background report on the state of technology in India and an IT Action Plan with 108 recommendations [10,11]. The Task Force could act quickly because it built upon the experience and frustrations of state governments, central government agencies, universities, and the software industry. Much of what it proposed was also consistent with the thinking and recommendations of international bodies like the World Trade Organization (WTO), International Telecommunications Union (ITU), and World Bank. In addition, the Task Force incorporated the experiences of Singapore and other nations, which implemented similar programs. It was less a task of invention than of sparking action on a consensus that had already evolved within the networking community and government.

Prime Minister Vajpayee captured the changing attitude toward technology in India in his claim that "IT is India's Tomorrow" [13]. This assessment offers a vision of a 21st century India substantially different from that of the 20th century. With its high levels of poverty, bloated and corrupt bureaucracies, protectionist policies, and large size, 20th century India was like the Asian elephant, plodding and turning slowly. At the dawn of a new millennium, Vajpayee and a growing number of politicians, bureaucrats, industry leaders, foreign investors, and bright-eyed entrepreneurs are trying to teach this Asian elephant to dance [14]."

All Publications button
1
Publication Type
Policy Briefs
Publication Date
Journal Publisher
CISAC/GTISC
Authors
Paragraphs

With the significant changes in the Asian-Pacific security environment in the post-Cold War era, cooperation in the region becomes both attainable and necessary. Because the ocean plays such a significant role in the Asian-Pacific region, maritime security is becoming a vital element in regional cooperative security.

This paper argues that maritime security-including transparency measures, confidence building measures (CBMs), and naval arms control-is critical for cooperative securityin the region. Maritime security measures should be undertaken in both. undisputed and disputed
sea areas. When adopted in disputed sea areas, these measures help guarantee regional peace.

China would support these measures. Preoccupied with reform and economic buildup, China seeks to maintain peace and stability in the region, and would participate in AsianPacific security arrangements. China does not intend to become a blue-water power. Rather it plans to enter and support a maritime security process in cooperation with other countries in the region.

All Publications button
1
Publication Type
Working Papers
Publication Date
Journal Publisher
CISAC
Authors
Subscribe to Water